HealthDay (9/24, Gotkine) reports a study found that “physical frailty may contribute to the development of dementia.” The researchers observed that “the risk for dementia was significantly higher in those with prefrailty and frailty compared with nonfrail individuals. Compared with those with low genetic risk and nonfrailty, the highest risk for dementia was seen for participants with frailty and high genetic risk.” They highlighted that a “potential causal relationship was seen between physical frailty and dementia in the forward Mendelian randomization (MR) analysis, while a null causal association was suggested in the reverse MR. Potential underlying mechanisms linking physical frailty to dementia include genetic background and neurologic and immunometabolic function.” The study was published in Neurology. (SOURCE: APA Headlines)