HealthDay (6/3, Gotkine) reports an umbrella review and meta-analysis found that “depression across the life course is associated with an increased risk for dementia.” Nine reviews were eligible for inclusion in the umbrella review; “the meta-analyses included 18 studies reporting depression onset late in life…and seven studies reported depression assessed during midlife.” Researchers observed that “depression present in late life and midlife significantly increased the risk for all-cause dementia based on pooled hazard ratios.” They concluded the results demonstrate “that depression across the life course, particularly in later life, is associated with an increased risk of dementia, suggesting it may function both as a prodromal symptom and a modifiable risk factor. This highlights the potential need for targeted screening and depression management in older adults especially.” The study was published in eClinicalMedicine. (SOURCE: APA Headlines)