Contemporary ObGyn (10/25, Ebert) reported a study presented at The Menopause Society’s 2025 Annual Meeting found that “women are significantly more likely than men to develop Alzheimer’s disease, and earlier menopause has been linked to an increased risk for late-life cognitive decline.” Furthermore, “this risk may be even greater in women who carry the APOE ε4 gene variant or who have systemic inflammation.” Study researchers observed that “over an average follow-up of 8 years, earlier age at menopause was associated with faster memory decline.” They found a “significant 3-way interaction was found between age at menopause, APOE ε4 status, and time. Women who carried the APOE ε4 variant showed stronger associations between earlier menopause and accelerated memory decline compared with noncarriers. Among the subset of women with available inflammatory data, higher levels of age-related inflammation further exacerbated the effect of earlier menopause on memory decline.” (SOURCE: APA Headlines)