Healio (4/13, Herpen) reported, “Older adults with late-onset major depressive disorder [MDD] and anxiety or substance use disorders were more likely to experience treatment-resistant depression,” investigators concluded in a study that assessed “27,189 eligible participants, who were aged 65 years or older and diagnosed with first-episode MDD, taken from the Taiwan National Health Insurance Database between Jan. 1, 2001, and Dec. 31, 2010.” Next, “one year follow-up was” evaluated “for incidence of resistance to treatment, defined as failure to respond to at least two antidepressants, with treatment-resistant tendency…defined as unresponsiveness to the first antidepressant.” The findings were published online March 23 in the Journal of Clinical Psychiatry. (SOURCE: APA Headlines)