MedPage Today (5/22, George) reports a study found that “older adults whose cognitive symptoms were more severe than their biological Alzheimer’s disease stage often had additional pathologies.” Researchers observed that patients “with more advanced clinical impairment compared with their biomarker-based Alzheimer’s stage often were positive for alpha-synuclein pathology or had higher neurofilament light (NfL) levels, a TAR DNA-binding protein 43 (TDP-43) imaging signature, or more cerebral small vessel disease than a reference group.” They said the findings are in line with neuropathology studies “showing that the presence of multiple pathologies is the norm rather than the exception with advanced age and neurodegenerative disease.” The study was published in JAMA Neurology. (SOURCE: APA Headlines)