Medscape (8/2, Yasgur, Subscription Publication) reports a study published online in JAMA Network Open “sheds light on the neurologic underpinnings of late-life depression…with apathy and its frequently poor response to treatment.” Researchers “analyzed baseline and posttreatment brain MRIs and functional MRIs…of older adults with depression who participated in a 12-week open-label nonrandomized clinical trial of escitalopram.” The team found disturbances “in resting state functional connectivity…between the salience network…and other large-scale networks that support goal-directed behavior, especially in patients with depression who also had features of apathy.” (SOURCE: APA Headlines)