Medscape (6/7, Lowry, Subscription Publication) reports, “Treating insulin resistance may improve treatment-resistant bipolar depression,” investigators posited in a 26-week study that randomized “20 patients to receive metformin and 25 patients to placebo.” The study revealed that “the diabetes drug metformin reversed insulin resistance in 50% of patients, and this reversal was associated with significant improvement of depressive symptoms.” The findings were presented at the American Society of Clinical Psychopharmacology’s annual meeting. (SOURCE: APA Headlines)